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Jeonghyeon Kwon

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Open access Aug 2026

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice

Orphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor GPRC5B and show here that both its mutation and inhibition by a d...

Jeonghyeon Kwon, Margherita Persechino, Jingchen Shao et al. · 0 citations

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