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Jeongeun Kim

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Review Open access Sep 2026

Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.

Synthetic lethality has established DNA-damage response (DDR) dependencies as a major strategy for precision cancer therapy, exemplified by targeting BRCA1/2 and poly(ADP-ribose) polymerase (PARP). However, genetic dependency alone does not ensure pharmacological tractability or clinical utility. Emerging targets, incl...

Nayoon Jo, Su-Jin Kang, Jeongeun Kim et al. · 0 citations

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