Author

Jennifer Listgarten

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Open access Jul 2026

Activity and specificity trade-offs in adenine base editors

This work found that the ABEs were fully described by the single dimension of intrinsic deaminase activity with no evidence for independent specialization with respect to local sequence context, editing window width, RNA editing, RNA editing, or genotoxicity.

Maria Lukarska, L. Oltrogge, Hunter M. Nisonoff et al. · bioRxiv · 1 citation

Jul 2026

Property guidance for protein sequence generative models with ProteinGuide.

ProteinGuide is applied jointly with wet-lab data generation to increase the editing activity of an adenine base editor in vivo, resulting in a base editor with higher editing efficiency than was previously achieved using seven rounds of directed evolution.

Junhao Xiong, Ishan Gaur, Maria Lukarska et al. · Nature Biotechnology · 1 citation