Open access
Sep 2026
Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis
Using cell lines in which ACLY is localized to either compartment, it is found that ACLY in either location supports fatty acid synthesis and histone acetylation, yet compartment-localized ACLY enables finer control, providing more precise regulation.
Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al.
· Science Advances · 0 citations