In silico and in vitro NAMs including quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (quantitative) structure–activity relationship ((Q)SAR) modeling for toxicity prediction and drug–drug interaction assessment, and multi‐omics approaches for pharmacodynamic biomarker discovery are desc...
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi et al.· Clinical pharmacology and th...· 0 citations
A select set of cases in neurology, psychiatry, addiction, anesthesia, and analgesia, where MIDD approaches were utilized to address critical drug development questions or fill knowledge gaps are summarized to offer insights into the utility of MIDD approaches to streamline drug development and opportunities to save co...
Michael Bewernitz, A. Nookala, Gopichand Gottipati et al.· Journal of clinical pharmaco...· 0 citations
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