Open access
Jul 2026
Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.
It is revealed that constitutive Notch2 experience affords lipopolysaccharide (LPS) hyperresponsiveness in Notch2-independent follicular B cells, which resulted in earlier Myc induction and accelerated cell cycle entry, ultimately augmenting division kinetics.
Jennifer Londregan, Isaiah Rozich, Brian T. Gaudette et al.
· Cell Reports · 0 citations