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Author

Jeffrey N. Law

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Open access Sep 2026

Targeted mutagenesis of a thermophilic mevalonate kinase for efficient catalysis at lower temperatures.

Thermophile-derived enzymes are of interest for cell-free biocatalysis due to their intrinsic thermostability, which simplifies purification via heat treatment and correlates with enhanced activity retention under cell-free reaction conditions. However, thermal stability often comes at the expense of slower turnover ra...

Sylvia A. Sarnik, Jeffrey N. Law, S. Mallinson et al. · 0 citations
Review Jul 2026

The Advantages of AI for Computational Protein Studies and Looking Ahead at the Next Challenges: Single Structures Are Not Enough.

Addressing and predicting ligand-binding sites in protein structures, as well as the prediction of reliable structures of proteins interacting with other proteins, will be pivotal for fully details of structural mechanisms and dynamics.

Pradeep Bk, Shi-Jie Chen, R. Dima et al. · 1 citation

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