Jeffery B. Klauda

Parameterization of the CHARMM Force Field for Divalent Cations (Ca2+/Be2+) binding to Anionic Lipids with Isothermal Titration Calorimetry

Beryllium toxicity manifests as a rare lung disease, berylliosis, characterized by persistent granulomas. Studies indicate that, in the presence of Be2+, macrophage phagocytosis is markedly reduced, potentially hindering the removal of apoptotic cells. Although the exact mechanism by which Be2+ ions reduce phagocytosis...