Tovorafenib demonstrated single-agent clinical activity in solid tumors with BRAF fusions or CRAF fusions or amplification and had a manageable safety profile and may offer a new targeted treatment option for adult patients with tumors harboring these rare genomic driver alterations.
M. Vieito, E. Cabanas, I. Mehmi et al.· JCO Precision Oncology· 0 citations
Simple Summary Melanoma is a serious skin cancer, and in East Asian patients it frequently arises at acral sites or on internal mucosal surfaces rather than on sun-exposed skin. These forms tend to respond less well to immunotherapy, the current standard first-line treatment, yet it remains unclear which tumors benefit...
Seo Yoon Jang, Minsuk Kwon, Jeeyun Lee et al.· Cancers· 0 citations
In metastatic disease, EOCRC shares a conserved canonical genomic backbone with AOCRC, indicating that it is not a genomically distinct entity, which suggests that CRC arising at younger age may reflect distinct age-associated biological vulnerabilities.
J. Shin, Eunbyeol Lee, Yun-Ha Sang et al.· JCO Precision Oncology· 0 citations
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