Reactive Polymer-Engineered Dual-Targeting Fluorescent Lipid Nanoparticles for Enhanced saRNA Delivery.
Lipid nanoparticles (LNPs) are widely explored as delivery vehicles for self-amplifying RNA (saRNA); however, incorporation of surface functionalities, such as fluorescent dyes for imaging and ligands for targeted delivery, remains challenging. In this study, we introduce a reactive poly(pentafluorophenyl acrylate) (PP...