Jean K. Chung

Small-Molecule Inhibitors Allosterically Control Bruton’s Tyrosine Kinase Assembly on the Membrane

Bruton’s tyrosine kinase (Btk) is targeted by small-molecule active-site inhibitors used to treat lymphomas and leukemias. Beyond its catalytic activity, Btk participates in signaling assemblies through scaffolding functions that can contribute to drug resistance. Here, we show that Btk forms micron-scale assemblies on...