Author

Je-Jia Wu

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Open access Jul 2026

Hydrogen peroxide as a multifaceted regulator of the Atg4 protease and autophagy in the pathogenic fungus Alternaria alternata

Findings indicate that H₂O₂ has multifaceted effects on AaAtg4 in a dosage-dependent or threshold-specific manner, which may position AaAtg4 as a central integrator of cellular stress responses and secondary metabolism, thereby advancing the understanding of fungal pathogenicity and environmental adaptation.

Hsin-Yu Lu, Je-Jia Wu, C. H. Y. Choo et al. · Frontiers in Fungal Biology · 0 citations

Open access Aug 2026

Autophagy-related protein 4 contributes to siderophore biosynthesis, toxin production, and virulence in Alternaria alternata.

It is demonstrated that AaAtg4 is important for spore germination, siderophore biosynthesis, iron acquisition, oxidative stress resistance, and toxin production, thereby establishing its critical role in A. alternata virulence.

Hsin-Yu Lu, C. H. Y. Choo, Je-Jia Wu et al. · Fungal Genetics and Biology · 0 citations