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Author

Jay P. Powers

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Jul 2026

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity.

A highly selective small-molecule KIT inhibitor is described that exhibits excellent broad kinome selectivity, with a selectivity score of S(50%) = 0.003, demonstrated promising in vivo therapeutic efficacy in an SCF-driven acute cutaneous anaphylaxis model in rodents.

Karen Y. Chen, Shiwei Qu, Xue-Lei Yan et al. · 1 citation

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