Engineering robust fermentation hosts remains a barrier to scalable biomanufacturing. In this work we replace canonical mixed-acid fermentation in
Escherichia coli
with a redox‑balanced reverse β‑oxidation (rBOX) pathway that produces medium‑chain fatty alcohols and is bioenergetically equivalent to ethanol ferme...
Bridgie Cawthon, Aidan E. Cowan, Zen Yoshikawa et al.· Nature Communications· 0 citations
Advances in metabolic engineering have enabled the integration of diverse non-native reactions into microbial hosts, providing sustainable alternatives to petrochemical manufacturing. We previously developed a modular polyketide synthase (PKS)-based platform in Streptomyces albus for producing 17 diols, amino alcohols,...
Q. Dan, Xi-Na Wang, Yan Chiu et al.· Metabolic Engineering· 0 citations
Coumarins and their derivatives possess diverse bioactivities and broad applications in pharmaceuticals, food additives, and materials science. For example, amino-functionalized coumarin derivatives hold significant promise for the development of novel functional materials and drug discovery. However, the microbial bio...
