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Author

Jason A. Papin

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Open access Sep 2026

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer’s disease (AD), but the metabolic mechanisms underlying early neuronal dysfunction remain incompletely understood. GABAergic neurons, which maintain excitatory–inhibitory balance and network stability, exhibit early vulnerability during neuro...

Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía et al. · 0 citations
Open access Jul 2026

Integrating multi-omics data with network modeling to characterize Pseudomonas aeruginosa persister cell metabolism

This study reveals that persister cells retain active metabolism and exhibit a metabolic program distinct from that of untreated cells, and integrated transcriptomics, metabolomics, and genome-scale metabolic modeling to identify specific metabolic pathways that are critical for persister survival.

Joseph M. Ficarrotta, Anna S. Blazier, Aline Métris et al. · 0 citations

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