Nutrition is one of the few modifiable risk factors for health status. The diet-disease relationship, however, is highly complex, with many endogenous and exogenous factors contributing to risk and with variation in responses to diet between individuals. The 2020-30 National Institutes of Health (NIH) Strategic Plan for Nutrition Research states that precision nutrition is a unifying and holistic approach to developing comprehensive and dynamic nutritional recommendations relevant to both individual and population health. Recognizing the growing importance of advanced computational approaches in nutrition research, in 2022 the NIH Office of Nutrition Research and participating NIH Institutes and Centers published a Funding Opportunity Announcement for training programs in AI for Precision Nutrition (AIPrN) aiming to develop a new generation of the scientific workforce, literate in both nutritional and computer sciences, that leverages the growing data resources available for nutrition research to tackle complex and emerging health-disease associations. In this paper, we describe the approaches developed by the first four institutional awardees of the T32 AIPrN training grant, and we highlight applied strategies for interdisciplinary training, data integration, and methodological innovation as the research community prepares to analyze and interpret data generated by major initiatives such as the NIH-funded Nutrition for Precision Health Initiative.
Saurabh Mehta, S. Huey, Paraskevi Massara et al.· Journal of NutriLife· 0 citations
The growing global challenges of food insecurity posed by climate change, and micronutrient deficiencies have intensified interest in climate resilient, nutrient-dense functional foods. Purslane (Portulaca oleracea L.) is a promising candidate owing to its exceptional nutritional profile and adaptability to harsh agroecological conditions. This review provides a comprehensive and critical synthesis of existing literature on the agronomic management, nutritional composition, and functional food potential of purslane, with particular emphasis on its omega-3 fatty acid content and the role of nitrogen and mineral nutrition. The review reveals that purslane is a rich source of alpha-linolenic acid (ALA), vitamins (C and E), carotenoids, minerals, and diverse bioactive compounds with antioxidant and anti-inflammatory properties. However, its nutritional quality is highly variable and influenced by genotype, environmental conditions, cultivation systems, and nutrient management strategies. Nitrogen plays a dual role of enhancing biomass production while exerting complex, compound-specific effects on nutrient density, often leading to trade-offs between yield and quality. The novelty of this study lies in its integrated, multi-dimensional perspective that links agronomy, plant physiology, and nutritional science, moving beyond fragmented analyses in existing literature. It highlights the importance of genotype-by-environment interactions and introduces the concept of “nutritional efficiency” as a more appropriate framework than yield-focused optimization. This study contributes to knowledge by identifying critical gaps and proposing a systems-based approach for optimizing purslane as a sustainable, plant-based source of omega-3 fatty acids and functional nutrients, particularly in resource-constrained and climate-vulnerable regions.
Peter A. Y. Ampim, Eniola A. Faluyi, M. Salisu et al.· Frontiers in Plant Science· 0 citations
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