Author

Jan Padeken

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Open access Oct 2026

HP1 can act independently of H3K9 methylation to promote heterochromatin focus formation, gene repression, and organogenesis.

Histone post-translational modifications (PTMs) segregate genomes into heterochromatin and euchromatin by recruiting readers, such as Heterochromatin Protein 1, which binds methylation of histone H3 lysine 9 (H3K9me). Here, we report H3K9me-independent functions for the C. elegans HP1 orthologue HPL-2 and the H3K9 meth...

Colin E. Delaney, Lisa Fol, S. Gruenewald et al. · Molecules and Cells · 0 citations

Open access Aug 2026

DVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in C. elegans

DVE-1 immunoprecipitation followed by mass spectrometry revealed all the core components of the nucleosome remodeling and deacetylase (NuRD) complex as interaction partners, implicating DVE-1 in the coordination of NuRD complex activity in the context of telomere organization.

Jan Sluka, Alexandra R. Blake, Nadezda Podvalnaya et al. · iScience · 0 citations