Open access
Sep 2026
Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability.
p53 plays a central role in the DNA damage response, inducing repair, cell-cycle arrest or apoptosis. Its loss is associated with replication stress and genomic instability. While several underlying mechanisms were suggested, the primary triggers of catastrophic genomic events like chromothripsis, a known driver of tum...
Wisam Zaatra, George Philippos, Petr Smirnov et al.
· Molecules and Cells · 1 citation