Jan Olszewski

Epigenetic memory of epithelial–mesenchymal transition: linking transient plasticity to metastasis, therapy resistance, and immune evasion

It is argued that metastatic competence, therapy resistance, and immune evasion can be viewed as functional outputs of remembered plasticity rather than solely as consequences of a contemporaneous mesenchymal phenotype, positioning memory-bearing states as an important target for future therapeutic strategies.