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Jan Arel Solomon Orlino

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Review Open access 2026

The efficacy of NMDA receptor antagonists in neuropsychiatric and non-motor symptoms of Parkinson’s disease: a systematic review

ABSTRACT. Parkinson’s disease (PD) involves significant non-motor symptoms (NMS) linked to glutamate dysregulation. Objective: This review evaluates the efficacy of N-methyl-D-aspartate (NMDA) receptor antagonists (memantine and amantadine) for treating NMS. Methods: A search was conducted in the databases PubMed and C...

Jan Arel Solomon Orlino, Ma. Lourdes Corrales-Joson · 0 citations

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