James M. McDonnell

Antibodies targeting a shared epitope exploit IgE allostery to drive distinct functional outcomes

Significance Antibody discovery typically operates on the “same epitope, same function” paradigm. However, for dynamic proteins like immunoglobulin E (IgE), the primary mediator of allergic disease, this approach is overly simplistic. By characterizing four closely related antibodies that recognize the same epitope but...