Open access
Aug 2026
Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal Expansion
The LINC-seq platform, LINC-seq, recovered known cognate pairs from pooled libraries at up to 95% accuracy and performed simultaneous, library-on-library deep mutational scanning of both partners, and generalizes to any receptor-ligand pair whose trans-engagement drives a reporter.
L. Liu, Seung Won Shin, Kevin M. Joslin et al.
· bioRxiv · 0 citations