James H. Hurley

DFCP1-containing ER microdomains mediate lysosomal membrane repair

DFCP1 mediates concentration of the ER-associated lipid transport machinery at damaged lysosomes to promote their sealing in response to Ca2+ flux and PIK3C3 activation, and concludes that DFCP1 compromises cellular resistance to vacuolar damage induced by Listeria monocytogenes.

A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation.

Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system

The cryo-electron microscopy structure of the full-length human VPS4B hexamer in six-membered helical “spiral staircase” states suggests a mechanism for substrate-dependent hexamerization and priming of VPS4 for its ESCRT-III remodeling activity.