DMT1 Facilitates Heme-iron Absorption in Rats and Mice.
Mechanisms of heme-iron (HI) absorption remain uncertain. Heme is probably absorbed by receptor-mediated endocytosis; iron is then enzymatically liberated from heme within endosomes, or in the cytosol. If heme is catabolized in endosomes, a transporter, such as DMT1, would be required to export ionic iron into the cyto...
Yue He, Jacob S. Shine, S. Sriram et al.
· Blood · 0 citations