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Author

James A. Wells

2 papers indexed here

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Open access Sep 2026

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.

Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limited. Here, we identify targeted degradation of the selenium uptake receptor lipoprotein receptor-related protein 8 (LRP8) as an effective approach to decrease the abundance o...

Fang-Zhu Zhao, Alex Inague, Trenton M. Peters-Clarke et al. · 0 citations
Open access Aug 2026

Structural and mechanistic analyses reveal collaborative regulation of HSF1 by the Hsp70-Hsp90 chaperone systems

A FRET-based approach to simultaneously monitor HSF1 conformational change and oligomeric state throughout activation and inactivation is developed and previously contradictory view on Hsp90’s role in HSF1 regulation is unify.

T. Owens, K. Schaefer, Trenton M. Peters-Clarke et al. · 0 citations

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