Jalal Naghinezhad

Reprogramming tumor-associated macrophages in breast cancer: from myeloid plasticity and tumor-promoting programs to CAR-macrophage therapy

Breast cancer develops within spatially organized, multicellular microenvironments in which particular tumor-associated macrophage (TAM) states can influence immune access and stromal remodeling. Conventional M1/M2 classification and total macrophage density fail to capture the developmental, transcriptional, metabolic...

Beyond the Generic Tumor: Engineering Patient-Specific Immune Ecosystems for Cancer.

Current evidence supports personalized immunotherapy as a promising approach for improving the precision of cancer treatment, but its clinical application remains constrained by biological, technical, manufacturing, regulatory, and clinical challenges.

Platelet-derived mitochondrial transfer in cancer metastasis: mechanisms, functional consequences, and translational opportunities