Jakub Pobideł

The comparison of graft types in anterior cruciate ligament (ACL) reconstruction in athletes: a literature review

Background. Rupture of the anterior cruciate ligament (ACL) is one of the most common and devastating injuries in sports orthopaedics. Its incidence rate is approximately 68.6 per 100,000 person-years and it represents over 50% of all knee injuries. The risk is exceptionally high among athletic populations, with female...

Targeting KRASG12C in non-small cell lung cancer: evidence from randomized clinical trials and future therapeutic strategies

Background The Kirsten rat sarcoma viral oncogene homolog G12C (KRASG12C) mutation is no longer an “elusive” target, having become an important therapeutic target in non-small cell lung cancer (NSCLC). The approvals of sotorasib and adagrasib have significantly altered the second-line treatment algorithm. This systemat...

QUALITY IN SPORT

How Has the Approach to Treating Childhood Obesity Changed in Recent Years: Literature Review

Overweight and obesity in children represent a serious global problem, with prevalence rates rising steadily in both developed and developing countries. Effective strategies for the prevention and treatment of childhood obesity require a comprehensive approach that takes into account individual, family, social and educ...

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Dato-DXd demonstrates robust clinical activity in patients with BC, providing superior disease control with a favorable safety profile compared to conventional chemotherapy, and preclinical data suggest that the induction of ICD may contribute to reshaping a heterogeneous TME.