Jakub Began

When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome.

Inflammatory caspases play essential roles in regulating IL-1 cytokine processing and secretion, as well as in inducing pyroptosis as part of the innate immune response to pathogens and other noxious stimuli. While the activation of caspase-1 is controlled by dedicated pattern recognition receptors, human caspase-4 and...