Structure-Guided Design of a Subnanomolar Dengue Virus NS4B Inhibitor.
Dengue virus nonstructural protein 4B (NS4B) is an essential regulator of viral replication but remains structurally unresolved, limiting drug discovery. Here, we combine modeling, ligand-based design, and experimental validation to enable structure-guided inhibition of NS4B. Comparative models across all four serotype...