Jacquelyn Jacobs

Kainate receptors coordinate primitive hematopoiesis and hemogenic niche organization to promote hematopoietic stem cell development

The adult hematopoietic system is established during embryogenesis through the generation of hematopoietic stem and progenitor cells (HSPCs) within specialized transient niches, yet the signaling mechanisms that coordinate this process remain poorly understood. Here, we identify a developmental role for kainate recepto...

Dishevelled 2 coordinates aortic Notch signaling through primitive myeloid and hemogenic endothelial cells during hematopoietic stem cell specification