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Author

Jacquelyn A. Myers

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Open access Sep 2026

PRC2 loss in MPNST is accompanied by SWI/SNF complex rewiring and sensitization to SMARCA2/4 and BET inhibition in vivo.

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas of peripheral nerve sheath that frequently arise in patients with neurofibromatosis type 1 (NF1) and currently have no approved targeted treatment. Loss of Polycomb Repressive Complex 2 (PRC2) activity, through inactivating mutations in SUZ12 or...

Kirill Miachin, Marc A. Morgan, Guang-Feng Wang et al. · 0 citations
Open access Jul 2026

Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

Treatment with senescence-targeting therapy improves BM hematopoietic stem and progenitor cells in vivo in mice and ex vivo in cells from individuals with SCD and could represent a possible strategy to improve HSPC health, promote manufacture of high quality bespoke clinical products, and potentially enhance the safety...

Aditya Barve, Preeti Dabas, Adam B. Cornwell et al. · 2 citations

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