Open access
Jan 2026
Structural Genomics Defines PBRM1 Bromodomain Variant Function in ccRCC
Polybromo‐1 (PBRM1) modulates chromatin accessibility and transcription via six bromodomains that bind acetyl‐lysine residues on nuclear proteins. PBRM1 variants exist in ~40% of clear cell renal cell carcinoma (ccRCC) cases. PBRM1 loss correlates with improved responses to antiangiogenics and immune checkpoint blockad...
Karina L Bursch, Salomão D Jorge, A. Catlin et al.
· Human Mutation · 0 citations