Open access
Sep 2026
Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex.
An updated model for how the rixosome integrates its diverse enzymatic activities to regulate ITS2 processing is established and the human 5'-3' exoribonuclease XRN2 directly associates with RNase PNK and selectively degrades NOL9-phosphorylated RNA in vitro, thereby linking ITS2 processing by the rixosome to processiv...
Jacob Gordon, Savannah M. Seely, Huan-Chen Wang et al.
· Nucleic Acids Research · 0 citations