Review
Open access
Aug 2026
Mitochondrial-centric regulatory networks in MASLD: integrating quality control, organelle interactions, and gut-liver communication.
It is highlighted that dysregulated mitophagy and mitochondrial fragmentation promote lipid accumulation and inflammation, whereas the abnormal formation of mitochondria-associated membranes (MAMs) exacerbates calcium overload and oxidative stress, and short-chain fatty acids and bile acids derived from the gut differentially modulate mitochondrial bioenergetics.
Jing-Wen Liu, Ke-Wei Li, Yinggui Deng et al.
· Pharmacological Research · 0 citations