Cross-trait genomic analyses implicate the ITIH3 and ITIH4 locus in the shared genetic architecture of bipolar disorder and obsessive-compulsive disorder
Background: Bipolar disorder (BIP) and obsessive-compulsive disorder (OCD) frequently co-occur and show evidence of genetic overlap, yet the specific pleiotropic loci and their functional mechanisms remain unclear. Methods: We conducted large-scale genetic analyses using GWAS summary statistics for BIP and OCD, excludi...