Author

J. Yustein

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Open access Aug 2026

Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma

De deleting Reg-1 has cell- and non-cell-autonomous benefits, nominating Reg-1 KO B7-H3-CAR T cells as a promising cell product for early-phase clinical testing in patients with solid tumors.

A. Adeshakin, Hao Shi, S. Perry et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions

SPARC is presented, a graph-based optimization framework that quantifies similarity in a shared high-dimensional latent space and reconstruct directional trajectories under biological constraints and is the first to propose a “cross-organ bone-like microenvironment” hypothesis.

Shifeng Wu, W. C. Walker, Carolyn A. Martin et al. · bioRxiv · 0 citations