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Author

J. Whitwell

3 papers indexed here

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Open access Sep 2026

Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes

Abstract Clinical syndromes of frontotemporal dementia present both distinct and overlapping neuroimaging abnormalities and, consequently, domains of impairment. The aim of this study was to determine how well covariance patterns from multiple neuroimaging modalities discriminate across clinical frontotemporal dementia...

Irene Sintini, Neha Singh-Reilly, Farwa Ali et al. · 0 citations
Open access Sep 2026

Pilot Multimodal Imaging Assessment of Neuropathological Iron Deposition and Molecular PET in Frontotemporal Lobar Degeneration

Background/Objectives: The role of iron in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) has been debated. However, the effects of iron on protein burden in these diseases remain poorly elucidated. We hypothesized that there is an association between iron deposition and tau and beta-amyloid depo...

Rodolfo Gabriel Gatto, Hossam Youssef, Gökhan Uruk et al. · 0 citations
Open access Jul 2026

Diffusion MRI Is More Sensitive Than Tau PET and Regional Volume Loss in Corticobasal Syndrome

White matter microstructural disruption is a dominant imaging signature of CBS and is more closely linked to gray matter volume loss than to measurable uptake on tau PET, while dMRI, particularly MD and ICVF, may provide greatest sensitivity for detecting disease-related changes in CBS.

Yu-Qi Tian, Ryota Satoh, V. Lowe et al. · 0 citations

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