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J. Wachtveitl

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#protein folding Open access Oct 2026

De novo design of light-controlled conformational protein switches

Light-responsive proteins offer the ability to control biology at an unmatched resolution. Yet, optogenetics is limited to a relatively small number of natural and engineered photoreceptors. The design of light-responsive proteins with native-like complexity is challenging as they must incorporate a light-responsive ch...

Alexander T. Hilditch, N. Goldbach, Chen-Xuan Liu et al. · 0 citations
Open access Aug 2026

Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12

G12 is identified and mechanistically characterise G12, a doxycycline-binding aptamer with remarkably high regulatory performance in yeast and human cells, and evidence that RNA Capture-SELEX efficiently enriches aptamers with ligand-responsive conformational switching is provided.

J. Hoetzel, A. Walbrun, M. Schäfer et al. · 0 citations

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