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Author

J. Vreede

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2 papers indexed here

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Open access Sep 2026

Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β‐lactamases

Rigid enzymes catalyze chemical reactions by stabilizing the transition state through a specific conformation. Catalytic residues are precisely positioned, and enzyme dynamics are kept to a minimum. It is thought that conserved residues around the active site (second‐shell residues) play a crucial role in positioning c...

Cristina V. Lopez-Gallego, Monika Timmer, J. Vreede et al. · 0 citations
Open access Sep 2026

A Mobile Glycosylation Locus Modulates Cell Wall Architecture in Lactobacillus crispatus.

Lactobacillus crispatus dominance in the vaginal microbiome is associated with beneficial health outcomes, yet strain-level variation and its implications remain poorly understood. Here, we resolve the genomic context of three glycosyltransferase gene fragments (GT1-3) previously linked with dysbiotic states. Long-read...

P. Achterberg, M. Lekkerkerker, L. Koelemeijer et al. · 0 citations

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