The isoform-specific, farnesylated hypervariable region (HVR) of Ras plays an important role in the organization and oligomerization of its globular domain (G-domain) on the surface of the membrane and can control downstream effector binding by positioning the G-domain on the membrane in a specific orientation.
A. Trifan, Hossein Omidi Ardali, J. Vermaas et al.· Membranes· 0 citations
The growing number of patients susceptible to invasive Candida albicans infections has intensified the need for effective antifungal targets in pathways essential for fungal growth and pathogenesis. Among these pathways, phosphate homeostasis has emerged as a significant determinant of virulence, yet how phosphate avai...
Direct solar-to-chemical conversion offers a compelling route to clean, dispatchable energy. Photosystem I (PSI), an evolutionarily optimized light-driven oxidoreductase, can be repurposed for solar-fuel production by coupling its photochemistry to catalytic interfaces. However, the molecular determinants that govern p...
Maximino D. Emerson, Siva Naga Sai Damaraju, Audrey H. Short et al.· ACS Nano· 0 citations
AlphaFunctor is a category theory based foundation model-like platform to bridge the gap between protein function annotation and property prediction, based on the hypothesis that protein function and properties can be directly derived from protein sequence.
Xiang Liu, Anna E. Yee, J. Vermaas et al.· arXiv.org· 0 citations
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