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Author

J. Vance

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Open access Sep 2026

Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish

Heritability estimates suggested that common variants explain much of genetic risk among APOE-{varepsilon}4 carriers, while unexplained heritability remains in non-carriers in the Amish, and GWAS confirmed APOE-{varepsilon}4 as the strongest genetic determinant of AD in the Amish.

Yi-Ning Liu, Yeunjoo E. Song, Wei-Huan Wang et al. · 0 citations
Open access Aug 2026

Methylation clocks fail to generalize across genetically admixed individuals

Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...

Sebastián Cruz-González, Ogechukwu Okpala, Esther Gu et al. · 0 citations

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