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Author

J. van Noort

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Open access Aug 2026

Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility

Using synthetic chromatin fibres assembled from physiologically relevant DNA sequences, it is shown that nucleosome positioning dictates the material state of chromatin, indicating that nucleosome positioning tunes chromatin toward or away from critical structural states that couple genome protection, chromatin dynamic...

Waad Albawardi, Matthew Thomas, Gert-Jan Kuijntjes et al. · 0 citations
Open access Aug 2026

Mixing chromatin fibers with different nucleosome repeat lengths changes dynamics of chromatin phase separation

The eukaryotic genome is organized into chromatin at multiple lengths and timescales. Liquid-liquid phase separation has recently emerged as a mechanism for the dynamic compartmentalization of chromatin. However, it remains unclear how cells can locally alter phase separation behavior to condense, decondense, and segre...

Jeremy Ernst, Beatriz Orozco Monroy, J. van Noort · 0 citations

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