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J. Van Drie

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Review Open access Oct 2026

Glucocorticoid receptor modulation as a host-directed strategy for inflammatory priming across chronic disease states

Chronic inflammation is increasingly recognized as a shared feature across neuropsychiatric, neurodegenerative, metabolic, oncologic, and post-infectious disorders, yet treatments mainly target downstream effects. Evidence suggests dysregulated glucocorticoid receptor (GR; encoded by NR3C1 ) signaling may regulate...

R. Slayden, R. Tjalkens, Neil D. Theise et al. · 0 citations
Preprint Sep 2026

The Principle of Minimum Justified Correlation

It is shown that Shannon entropy, Fisher information, and quantum-mechanical kinetic energy may all be viewed as measures of correlation. We begin with a fundamental correlation-destroying map: a joint probability density $\rho(x,y)$ is replaced by $\rho_x(x)\rho_y(y)$, the product of its marginal distributions. In the...

J. Van Drie · 0 citations

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