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Sep 2026

CSF3R compound mutations produce a hyperproliferative leukemia driven by overexpression of PIM kinases.

Colony Stimulating Factor 3 Receptor (CSF3R) mutations are the molecular hallmark of chronic neutrophilic leukemia (CNL). A subset of these patients (~25%) have two mutations in CSF3R on the same allele. These "compound" CSF3R mutations include both an activating point mutation and a cytoplasmic truncating mutation. Wh...

Breanna N. Maniaci, Jacob Edward Porter, Hanqian L. Carlson et al. · 0 citations

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