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J. Tjon

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Open access Aug 2026

Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrow

This comprehensive spatial map of the AML bone marrow identified tripartite crosstalk between AML, macrophages, and T cells mediated by the Galectin-9 – CD44/TIM-3 axis as a key component of the immunosuppressive microenvironment.

M. van der Meulen, Emma S. Pool, A. Perzolli et al. · 0 citations
Open access Aug 2026

Long-term outcome of a DLI-based treatment strategy in patients with relapsed AML after TCD allogeneic stem cell transplantation is hampered by GvHD and late relapse.

BACKGROUND Relapse of acute myeloid leukemia (AML) after allogeneic stem cell transplantation (alloSCT) remains a major cause of treatment failure, with poor long-term survival. Donor lymphocyte infusion (DLI) can induce a graft-versus-leukemia effect but may also lead to graft-versus-host disease (GvHD) associated mor...

J. Bergsma, E. Argiro, K. Oosterink et al. · 0 citations

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