Tumor progression is driven by cancer cells’ ability to establish a cellular network through tunneling nanotube-like connections (TNTs), which enable mitochondrial exchange both within the tumor cells and with the tumor microenvironment (TME). However, the functional consequences of mitochondrial transfer between tumor...
Inés Saénz-de-Santa-María, Anna Pepe, J. Tinevez et al.· Nature Communications· 1 citation
Bacterial proliferation in confined spaces occurs in biofilms, intracellular compartments, or infection sites, generating mechanical constraints. We investigated how growth-induced mechanical pressure affects bacterial physiology using a microfluidic device ensuring nutrient access. We found that proliferating Escheric...
Laure Le Blanc, Baptiste Alric, Romain Rollin et al.· Nature Communications· 0 citations
These findings uncover a previously unrecognized mechanism of LEN action, whereby capsid stabilization reprograms the nuclear fate of the HIV-1 genome in macrophages, limiting integration and redirecting viral DNA toward more repressive nuclear environments, likely shaping the transcriptional potential of newly integra...
Thierry Mourer, M. Harastani, Celine Cuche et al.· Science Advances· 0 citations
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously showed that choanoflagellates, the closest living relatives of animals and classically viewed as obligate flagellated swimm...
Maite Freire-Delgado, Diede de Haan, Stéphane Tachon et al.· bioRxiv· 0 citations
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