Abstract Background and aims Heart failure with preserved ejection fraction (HFpEF) phenotypes have been characterised as static entities in trial populations yet their temporal dynamics remain unexplored in routine clinical practice. We aimed to identify HFpEF phenogroups from real-world electronic health records (EHR...
S. Brown, F. Soltani, Jack Wu et al.· Open Heart· 0 citations
Background Laboratory-based frailty indices (FI-Lab) have shown promise in geriatric medicine research. We aimed, in diverse samples, to determine the optimal construction of an FI-Lab for acute care and evaluate its validity as a measure of latent health status across the adult life span. Methods and findings Our retr...
H. L. Ellis, Peter Hanlon, Liam Dunnell et al.· PLoS Medicine· 0 citations
Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integrating and updating evidence across time and sources to form, revise and justify a patient's problem representation and a defensible plan. This structured narrative review...
We propose a rubric for assessing expressed clinical reasoning in model responses, drawing on three bodies of work: medical education assessment frameworks (ART, SCT, Key Feature Problems and OSCE); clinical LLM benchmarks (MedR-Bench, HealthBench, TIMER-Bench, DR. BENCH, PrIME-LLM and PatientSafeBench); and general LL...
Zhang Jiang, Zina Ibrahim, J. Teo· 0 citations
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