The data suggest that despite the heterogeneity in CRC, genomic evolution increases the impact of recurrent alterations, and integrating information about tumor primary location and genomics can be used to predict organ-specific metastasis risk.
Paolo Manca, H. Walch, Jierui Xu et al.· Cancer Cell· 1 citation
Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.
Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al.· Nature· 0 citations
PRISM2 demonstrates how language-supervised pretraining provides a scalable, clinically grounded signal for generalizable pathology representations, bridging human diagnostic reasoning and foundation model performance.
E. Vorontsov, George Shaikovski, Adam Casson et al.· Nature Medicine· 3 citations
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