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J. Shia

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Open access Sep 2026

Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer

The data suggest that despite the heterogeneity in CRC, genomic evolution increases the impact of recurrent alterations, and integrating information about tumor primary location and genomics can be used to predict organ-specific metastasis risk.

Paolo Manca, H. Walch, Jierui Xu et al. · 1 citation
Open access Aug 2026

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.

Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al. · 0 citations
Open access Jul 2026

End-to-end multimodal pathology foundation model with clinical dialogue.

PRISM2 demonstrates how language-supervised pretraining provides a scalable, clinically grounded signal for generalizable pathology representations, bridging human diagnostic reasoning and foundation model performance.

E. Vorontsov, George Shaikovski, Adam Casson et al. · 3 citations

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