Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and can be divided into two major subtypes: fusion-positive (FP) RMS, which most commonly involves the PAX3::FOXO1 or PAX7::FOXO1 fusion gene, and fusion-negative (FN) RMS, which lacks these gene fusions. Previous DNA methylation studies have sho...
Wen-Yue Sun, J. Lopez-Nava, J. Shern et al.· Cancer Research· 0 citations
Many cancers are driven by mutationally altered transcription factors (TFs) that rewire cells to an oncogenic state. Cells must activate specific mechanisms to tolerate the burden of oncogenic TF activity. To define such mechanisms, we focused on a canonical oncogenic fusion protein-driven cancer, alveolar rhabdomyosar...
C. Delaney, Min Lu, S. Zimmerman et al.· Cell Reports· 0 citations
The Childhood Cancer Data Initiative (CCDI), a 10-year $50M per year data initiative, brings together doctors, researchers, and families affected by cancer to learn from every child diagnosed with cancer, speeding discovery for new medical advances. In partnership with the Children’s Oncology Group (COG), NCI launche...
Emily S. Boja, Subhashini Jagu, Joseph A. Flores-Toro et al.· Cancer Research· 0 citations
NB is identified as a highly NAMPT inhibitor-sensitive pediatric solid tumor and NAMPT-dependent NAD + biosynthesis as a targetable metabolic vulnerability in this disease is established.
Sophia Varriano, Amy Yu, Abantika Chakraborty et al.· Journal of Experimental &...· 0 citations
Findings reveal substantial plasticity among endothelial and osteosarcoma cells in human and murine metastatic osteosarcoma, provide new insight into the how the metastatic microenvironment shapes the tumor vasculature, and challenge current models of osteosarcoma biology.
