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Open access Oct 2026

Imbalanced ω-6/ω-3 polyunsaturated fatty acid metabolism promotes HFpEF progression via the ANGPTL4/LPL axis-mediated lipotoxicity

Heart failure with preserved ejection fraction (HFpEF) is a growing global burden with limited therapeutic options. While lipid metabolic disorders are hallmarks of HFpEF, the specific contribution of imbalanced -6/-3 polyunsaturated fatty acids (PUFAs) to myocardial lipid handling remains poorly understood. This...

Z. Zhang, J. Wang, W. Zhang et al. · 0 citations

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